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Cardiovascular

Cardiovascular Research

For over three decades, MultiCare Health System has conducted research in the South Sound region, each year advancing a richly diverse portfolio of studies.

Now, through an exclusive partnership between Pulse Heart Institute and MultiCare Institute for Research & Innovation, we are building on 33 years of community-based-research experience and expertise in an effort to offer an even more robust cardiac research program in the Pacific Northwest. Cardiovascular studies include the following therapeutic areas:

  • Aortic and mitral valves
  • Atrial fibrillation
  • CABG coronary artery bypass grafting
  • Congestive Heart Failure
  • Hyperlipidemia
  • Myocardial infarction
  • Novel anticoagulants
  • Peripheral artery disease
  • Pulmonary arterial hypertension

Learn more about capabilities surrounding cardiovascular research.

The Principal Investigators include:

Allen Graeve, MD, FACS

Tony Kim, MD

Brian Kott, MD

Vinay Malhotra, MD, FACC, FAHA

Kingson Momah, MD, FACC

Dennis Nichols, MD

Jaime Pugeda, MD

Tariq Salam, MD

Needham Ward, MD, FACC

Cardiac Studies Accepting Patients

Acute Coronary Syndromes

Acute Coronary Syndromes

Study Number: UPSTREAM – Utilization of Ticagrelor in the upstream setting for non-ST-segment elevation acute coronary syndrome (UPSTREAM): An ED-based clinical registry.

Study Info

Principal Investigator: Vinay Malhotra, MD, FACC, FAHA

Study Coordinator: Karyna Boykin, [email protected], 253-697-1301

Acute Myocardial Infarction

Paradise-MI

Study Number: CLCZ696G2301 – Prospective ARNI versus ACE inhibitor trial to determine superiority in reducing heart failure events after myocardial infarction.

Study Info

Principal InvestigatorVinay Malhotra, MD, FACC, FAHA

Study Coordinator: Karyna Boykin, [email protected], 253-697-1301

Cardiothoracic Surgery Studies

Atrial Fibrillation

AFIB—GENETIC-AF

Study Number: BUC-CLIN-303 - A genotype-directed comparative effectiveness trial of Bucindolol and Toprol-XL for prevention of symptomatic atrial fibrillation/atrial flutter in patients with heart failure.

Study Info

Principal Investigator(s): Vinay Malhotra, MD, FACC, FAHA

Study Coordinator: Tiffany Edwards, [email protected], 253-697-1302


AFIB - Elite Registry

Study Number: CV185-161 – Eliminate Thromboembolism: Improving anticoagulation  in non-valvular atrial fibrillation (ELITE).

Study Info

Principal Investigator: Vinay Malhotra, MD, FACC, FAHA

Study Coordinator: Tiffany Edwards, [email protected], 253-697-1302



Device

VEST AND VEST REGISTRY - A multicenter, randomized controlled trial to test the hypothesis that a non-invasive wearable cardioverter defibrillator (WCD) will reduce sudden death and death due to ventricular arrhythmia in the first 90 days following an MI in participants with left ventricular
dysfunction (EF less than 35%). To create a registry of VEST eligible patients for long-term follow-up to determine health and utilization outcomes. All VEST eligible patients study participants will be offered participation in the VEST registry including those who previously participated in VEST.

Study Info

Principal Investigator(s): Tariq Salam, MD

Study Coordinator: Tiffany Edwards, [email protected], 253-697-1302

Heart Failure

Heart Failure

Study Number: CLR325X2202 – A randomized, subject and investigator-blind, placebo-controlled study of CLR-325 in chronic stable heart failure patients.

Study Info

Principal InvestigatorVinay Malhotra, MD, FACC, FAHA

Study Coordinator: Karyna Boykin, [email protected], 253-697-1301


Heart Failure - AWAKE-HF

Study Number: CLCZ696BUS14 – a multicenter, randomized, double-blind, double-dummy, parallel group, active-controlled 8-week study and 8-week open-label extension to evaluate the effect of initiation of sacubitril/valsartan on objective measure of waking activity and sleep, as health-related quality of life functions in subjects with heart failure and reduced ejection fraction. 

Study Info

Principal InvestigatorVinay Malhotra, MD, FACC, FAHA

Study Coordinator: Karyna Boykin, [email protected], 253-697-1301


Heart Failure - Prove-HF

Study Number: CLCZ696BUS13 – a 52-week, open-label evaluation of the effects of sacubitril/valsartan (LCZ696) therapy on biomarkers, myocardial remodeling and patient-reported outcomes in heart failure with reduced left ventricular ejection fraction. 

Study Info

Principal InvestigatorVinay Malhotra, MD, FACC, FAHA

Study Coordinator: Janey Barnhart, [email protected], 253-403-7258

Hypercholesterolemia

R727-CL-1532

Study Number: R727-CL-1532 – a randomized, double-blind, placebo-controlled study to evaluate the effect of Praluent on neurocognitive function in patients with heterozygous familial hypercholesterolemia or with non-familial hypercholesterolemia at high and very high cardiovascular risk.

Study Info

Principal Investigator(s): Vinay Malhotra, MD, FACC, FAHA

Study Coordinator: Tiffany Edwards, [email protected], 253-697-1302

Hyperlipidemia

Esperion

Study Number: 1002-040—A randomized, double-blind, placebo-controlled, multicenter long-term
safety and tolerability study of ETC-1002 in patients with hyperlipidemia at high cardiovascular risk who are not adequately controlled by their lipid-modifying therapy.

Study Info

Principal Investigator(s): Vinay Malhotra, MD, FACC, FAHA

Study Coordinator: Tiffany Edwards, [email protected], 253-697-1302

Mitral Valve

ON-X VALVE

Study Number: 2005-01—Clinical trial of the On-X® Valve using low dose anticoagulation.

Study Info

Principal Investigator(s)Allen Graeve, MD & Dennis Nichols, MD

Study Coordinator: Janey Barnhart, [email protected], 253-403-7258


ON-X VALVE 17

Study Number: ON-X 2010-01—The indications for replacement of a patient’s natural or prosthetic valve will be those which the principal investigator follows in his routine practice of cardiovascular surgery.

Study Info

Principal Investigator(s)Allen Graeve, MD & Dennis Nichols, MD

Study Coordinator: Janey Barnhart, [email protected], 253-403-7258


ON-X POST-APPROVAL REGISTRY

On-XPAS: On-X aortic prosthetic heart valve low dose warfarin post approval clinical registry study.

Study Info

Principal InvestigatorDennis Nichols, MD

Study Coordinator: Janey Barnhart, [email protected], 253-403-7258

Pulmonary Arterial Hypertension

OPUS REGISTRY

Study Number: ACC-055-503 - Multicenter, long term, real-world, observational, drug registry of
patients newly treated with OPSUMIT (macitentan).

Study Info

Principal Investigator(s): Vinay Malhotra, MD, FACC, FAHA

Study Coordinator: Tiffany Edwards, [email protected], 253-697-1302

Stroke

Stroke

Stroke - Weave

Study Number: WEAVE - Wingspan StEnt System Post MArket SurVEillance Study; Prospective, single-arm, consecutive enrollment, post market surveillance study. The primary objective of this study is to evaluate the rate of stroke and death in patients treated with the Wingspan Stent System, according to the Indications for Use, within 72 hours post procedure.

Study Info

Principal Investigator(s): Brian Kott, MD

Study CoordinatorJaney Barnhart, [email protected], 253-403-7258


Stroke - Penumbra Smart Coil Study

Study Number: CLP 10023.A—A prospective, multicenter study assessing the embolization of neurovascular lesions using the Penumbra Smart Coil

Study Info

Principal Investigator(s): Brian Kott, MD

Study CoordinatorJaney Barnhart, [email protected], 253-403-7258


Stroke - Confidence Trial

Study Number: 2015-CL11003—Carotid stent trial to evaluate the safety and efficacy of the Roadsaver stent used in conjunction with the nanoparasol embolic protections system for patients at increased risk for adverse events from carotid endarterectomy.

Study Info

Principal Investigator(s): Brian Kott, MD

Study CoordinatorJaney Barnhart, [email protected], 253-403-7258