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Neurology Research

Clinical Research for Neurologic Diseases

The MultiCare Neuroscience Center of Washington has been active in the search for new and innovative treatments for many of the devastating neurologic diseases that affect our community. The MultiCare Research Institute has partnered with the MultiCare Neuroscience Center of Washington to provide research opportunities to our community in many areas of neurologic science including:

Multiple Sclerosis

John Huddlestone, MD and the site are nationally recognized for excellence. He has been involved in clinical trials for more then 2 decades. Trials are conducted at South Sound’s only nationally recognized Multiple Sclerosis Center. The site has participated in trials evaluating

  • First oral medications for treatment of MS
  • Monoclonal antibody therapy in MS
  • Novel therapeutics with specific targets in MS
  • Comparison of Disease Modifying Therapies in MS
  • Long-term follow-up trials after Exposure to Investigational Products

Post-Herpetic Neuralgia pain control

Restless Leg Syndrome control of symptoms

Migraine Headache treatment and suppression

Movement Disorders treatment

Epilepsy

Two Board Certified Epileptologists, Laura Hershkowitz, DO and Laura Lynam, MD offer clinical trials to patients with epilepsy.


The Investigators in Neuroscience medicine include:

Laura Hershkowitz, DO, FACN (Principal Investigator)

John Huddlestone, MD, FAAN (Principal Investigator)

Stacy Donlon, MD

Peter Kwon, MD

Laura Lynam, MD,

Traci Ryan, MD

Yu Zhu, MD, PhD

Neurology Studies Accepting Participants

Adults 

Multiple Sclerosis   

ACTH-MS

Study Number: ACTH-MS Fatigue—The effect of ACTH (Acthar®) on measures of fatigue in patients with relapsing multiple sclerosis.

Study Info

Principal Investigator(s)John Huddlestone, MD

Study Coordinator:  Jarrod Monroe, [email protected], 253-403-7449


Esteem

Study Number: 109MS401—A multicenter, global, observational study to collect information on safety and to document the drug utilization of Tecfidera™ (Dimethyl Fumarate) when used in routine medical practice in the treatment of multiple sclerosis (ESTEEM) to assess the efficacy and safety of TECFIDERA in the United States.

Study Info

Principal Investigator(s)John Huddlestone, MD, FAAN

Study Coordinator:  Jarrod Monroe, [email protected], 253-403-7449


Sanofi OBS13434

Study Number: OBS13434—A prospective, multi-center, observational, post-authorization safety study to evaluate the long term safety profile of LEMTRADA (alemtuzumab) treatment in patients with relapsing forms of multiple sclerosis.

Principal Investigator(s)John Huddlestone, MD, FAAN

Study Coordinator: Tonya Stigger[email protected], 253-403-1208


COMB157G2302

Study Number: ASCLEPIOS II—A randomized, double-blind, double-dummy, parallel group study comparing the efficacy and safety of ofatumumab versus teriflunomide in patients with relapsing multiple sclerosis.

Study Info

Principal Investigator(s)Stacy Donlon, MD

Study Coordinator:  Jarrod Monroe, [email protected], 253-403-7449


MNK14274069

Study Number: OPTIONS—A multicenter, radomized, double-blind, placebo-controlled parallel group, pilot study to assess the efficacy and safety of HP Acthar Gel in subjects with relapsing-remitting multiple sclerosis.

Study Info

Principal Investigator(s)Stacy Donlon, MD

Study Coordinator:  Jarrod Monroe, [email protected], 253-403-7449

Migraine

Evidera Observational Migraine

Study Number: 20150133—A  prospective observational study to evaluate tolerability and

outcomes of prophylactic therapies in migraine.

Principal Investigator(s)John Huddlestone, MD, FAAN

Study CoordinatorTonya Stigger, [email protected], 253-403-1208

Radiologically Isolated Syndrome

UTSMC

Study Number: ARISE—A multicenter, randomized, double-blinded assessment of Tecfidera in extending the time to a first attack in radiologically isolated sydrome (RISE).

Study Info

Principal Investigator(s)Stacy Donlon, MD

Study Coordinator:  Jarrod Monroe, [email protected], 253-403-7449

Pediatrics 

Tonic Clonic & Partial Onset Seizures

EISAI311

Study Number: E2007-G000-311—An open-label, multicenter, study with an extension phase to evaluate the safety, tolerability and exposure-efficacy relationship of perampanel oral suspension when administered as an adjunctive therapy in pediatric subjects (age 4 to greater than 12 years) with inadequately controlled partial-onset seizures or primary generalized tonic-clonic seizures.

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348


Pfizer A0081105

Study Number: A0081105—A randomized, double-blind, placebo-controlled, parallel group, multicenter trial of Pregabalin as adjunctive therapy in pediatric and adult subjects with primary generalized tonic-clonic seizures.

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348


Pfizer 207748

Study Number: A0081106—A 12-month, open-label study to evaluate the safety and tolerability of Pregabalin as adjunctive therpay in pediatric subjects one month to 16 years of age with partial onset seizures and primary generalized tonic-clonic seizures.

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348


Pfizer 208469

Study Number: A0081042—A double-blind, placebo-controlled, parallel-group, multicenter study of the efficacy and safety of Pregabalin as adjunctive therapy in children one month through <4 years of age with partial onset seizures.

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348

Lennox-Gastaut Syndrome

EISAI338

Study Number: E2007-G000-338—A multicenter, double-blind, randomized, placebo-controlled trial with an open-label extension phase of perampanel as adjunctive treatment in subjects at least 2 years of age with inadequately controlled seizures associated with Lennox-Gastaut Syndrome.

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348

Dravet Syndrome

Zogenix 1501

Study Number: ZX008-1501—A multicenter, randomized, double-blind, parallel group, placebo-controlled trial of two fixed doses of ZX008 (Fenfluramine Hydrochloride) oral solution as an adjunctive therapy in children and young adults with Dravet Sydrome.

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348


Zogenix 1503

Study Number: ZX008-1503—An open-label extension trial to assess the long-term safety of ZX008 (Fenfluramine Hydrochloride) oral solution as an adjunctive therapy in children and young adults with Dravet Syndrome.

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348

Partial Epilepsy

SEP093-364

Study Number: SEP093-364—An open-label Eslicarbazepine acetate long-term safety and tolerability study in children and adolescents (4 to 7 years).

Study Info

Principal Investigator(s)Steven Phillips, MD

Study Coordinator:  Cassidy Canorro, [email protected], 253-403-9348

Stroke

Stroke

Stroke - Weave

Study Number: WEAVE - Wingspan StEnt System Post MArket SurVEillance Study; Prospective, single-arm, consecutive enrollment, post market surveillance study. The primary objective of this study is to evaluate the rate of stroke and death in patients treated with the Wingspan Stent System, according to the Indications for Use, within 72 hours post procedure.

Study Info

Principal Investigator(s): Brian Kott, MD

Study CoordinatorJaney Barnhart, [email protected], 253-403-7258


Stroke - Penumbra Smart Coil Study

Study Number: CLP 10023.A—A prospective, multicenter study assessing the embolization of neurovascular lesions using the Penumbra Smart Coil

Study Info

Principal Investigator(s): Brian Kott, MD

Study CoordinatorJaney Barnhart, [email protected], 253-403-7258


Stroke - Confidence Trial

Study Number: 2015-CL11003—Carotid stent trial to evaluate the safety and efficacy of the Roadsaver stent used in conjunction with the nanoparasol embolic protections system for patients at increased risk for adverse events from carotid endarterectomy.

Study Info

Principal Investigator(s): Brian Kott, MD

Study CoordinatorJaney Barnhart, [email protected], 253-403-7258